Our group’s main interest is to unravel the molecular mechanisms that control tissue and organ repair in order to address health challenges that have high impact on the quality of human life.
The current research focus is on the role of cell metabolism and inflammation in tissue regeneration and cancer. We use a range of research approaches, such as advanced genetics, high-end microscopy and multi-omics analytics to investigate epithelial repair in Drosophila, retina and fin regeneration in zebrafish, and cancer biology using human organoids. We expect that these studies using animal and humans in-vitro model systems will contribute to a better understanding of tissue physiology and disease, which may lead to better diagnostics and novel therapeutic approaches based on the improvement of human regenerative capacity.
Immune-based approaches to improve Breast Cancer management
Team Members: Rute Salvador, Bruna Correia, António Jacinto, Maria Guadalupe Cabral (IR: firstname.lastname@example.org)
Breast cancer (BC) is the most common malignancy in women worldwide. Despite the vast ongoing research efforts, it remains a challenging disease to treat. Increasing evidences have been highlighting the role of inflammation and immune players in cancer progression and response to conventional treatments. Therefore, it is believed that a deeper understanding of BC immunobiology is needed for the implementation of more efficient and tailored treatments for this disease. Using patients’ clinical samples, our research is focused on finding particular immune traces in the tumor microenvironment of BC, that could be translated into accurate predictive/prognostic biomarkers or into new target therapies, ultimately aiming to ameliorate BC patients’ care.
Liga Portuguesa Contra o Cancro (Terry Fox Research Grant 2019); Tagus Tank Consortium (Research Prize in Medicine 2018); Pfizer/Sociedade das Ciências Médicas (Clinical Research Prize 2019); iNOVA4Health (UID/Multi/04462/2013-Lisboa-01-0145FEDER-007)
The kick-off meeting of the Associated Laboratory LS4FUTURE took place last May 4th, joining NMS with other institutes such as ITQB NOVA, IGC, iBET and IPO.
NOVA Medical SchoolCampo Mártires da Pátria, 1301169-056 LisboaPORTUGAL
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